DOSAGE AND ADMINISTRATION

For most patients, the recommended dose is 50 mg taken, as needed, approximately 1 hour before sexual activity. However, VIAGRA may be taken anywhere from 4 hours to 0.5 hour before sexual activity. Based on effectiveness and toleration, the dose may be increased to maximum recommended dose of 100 mg or decreased to 25 mg. The maximum recommended dosing frequency is once per day.

The following factors are associated with increased plasma levels of sildenafil: age >65 (40% increase in AUC), hepatic impairment (e.g., cirrhosis, 80%), severe renal impairment (creatinine clearance <30 mL/min, 100%), and concomitant use of potent cytochrome P450 3A4 inhibitors [ketoconazole, itraconazole, erythromycin (182%), saquinavir (210%)]. Since higher plasma levels may increase both the efficacy and incidence of adverse events, a starting dose of 25 mg should be considered in these patients. Ritonavir greatly increased the systemic level of sildenafil in a study of healthy, non-HIVinfected volunteers (11-fold increase in AUC, see Drug Interactions.) Based on thesepharmacokinetic data, it is recommended not to exceed a maximum single dose of 25 mg of VIAGRA in a 48 hour period.

VIAGRA was shown to potentiate the hypotensive effects of nitrates and its administration in patients who use nitric oxide donors or nitrates in any form is therefore contraindicated. Simultaneous administration of VIAGRA doses above 25 mg and an alpha-blocker may lead to symptomatic hypotension in some patients. Doses of 50 mg or 100 mg of VIAGRA should not be taken within 4 hours of alpha-blocker administration. A 25 mg dose of VIAGRA may be taken at any time.

OVERDOSAGE

In studies with healthy volunteers of single doses up to 800 mg, adverse events were similar to those seen at lower doses but incidence rates were increased. In cases of overdose, standard supportive measures should be adopted as required. Renal dialysis is not expected to accelerate clearance as sildenafil is highly bound to plasma proteins and it isnot eliminated in the urine.

For most patients, VIAGRA should not be taken more than once a day. In patients taking certain protease inhibitors (such as for the treatment of HIV), it is recommended to not exceed a maximum single dose of 25 mg of VIAGRA in a 48-hour period.

PERSONAL TESTIMONIES

I take 25mg on an empty stomach with a tall glass of water at 8:00AM. It takes effect in 15 minutes on the average and out love-making session goes for over an hour every time. - Age 65, Florida

I decided to try a 25mg Viagra pill. I could feel my penis get erect within 15 minutes, getting harder than usual and lasting longer too - YT, Age 45, Nigeria

A full 100 mg. will give you a Ginsu carving knife that, if put to ultimate use, will render her suitable for burial in a Y-shaped coffin. For most of us, 50 mg. is plenty, ensuring that you can return to a deflated state between orgasms, if so desired...But you may have to picture your grandmother naked, to do so.

The effects last 3 or 4 hours, and it takes 30 to 45 minutes to kick in. 25 or 50 mg tabs work the same for me, no difference. Go for it... - Art, Age 62, Texas

I bought a pill cutter at the grocery store and cut a 50 mg pill in half. It worked faster than a 1/2 hour and I had the first complete sexual experience in over 6 YEARS! William, Age 42, Texas

25mg is best for me and I have found that Viagra makes me a super stud and the girl rides me and always has an orgasm or two. - Pablo, 42, Texas

I find that 25 mg two hours prior to sex is best for me, and allows sensitivity, to remain at its peak. When trying 50 or 100,mg, it took away much of the feeling, and you need stimulation to maintain erection. More is definitely not better, in my case. - Phil, Age 60, California

25mg begins to work in about 15 minutes to a half an hour and lasts for 3 hours or so, Able to have an erection and intercourse more than once in a few hours. - Age 65, New York City

My doctor prescribed 50 mg Viagra. Wow. Instant hard on that lasts for a long time. I take 50 mg about three times a week. I have tried 100mg from time to time but actually seem to do better with the smaller doses. - JR, Age 65

You have to experiment with the dosage and time lag. I started with 50 mg (good to rev my engine, I think) but ultimately found that 25 mg about 90 minutes before sex is ideal for me. Lower dosage means less nasal congestion and more feeling during sex. But 25 mg still leaves me rock hard and able to hold off climaxing just about as long as I want.

I have experimented with dosage and now find that 25 mg about one half hour before sex is perfect for me. I'm rock hard and can go forever.

I have the pharmacist split a 100 mg pill in four for me so I take 25 mg at a time. When I want to go all night I take the full 100. I cut a 50 mg in half and find that to be enough.

We came at the same time, and boy did I cum. What force! What makes this whole experience ever better is that I only used half of a 50 mg pill.

I started off with 25 mg, and have reduced it down to 12.5 mg (roughly - I split the 100 mg pill to 8) and find that with this reduced dose, I can still have a rock hard erection as well as a greatly reduced headache.

I have since realized I only need 25mg to keep and maintain an erection. But originally, that night, I took 50mg. - Bill, Chicago, Age 42

HOW QUICKLY DOES VIAGRA WORK?

I take 50mg 15 minutes before love making, and now I can spend hours with foreplay and not worry if I'm gonna go soft or lose interest.

It takes effect in 15 minutes on the average and out love-making session goes for over an hour every time. - Age 65, Florida

I could feel my penis get erect within 15 minutes, getting harder than usual and lasting longer too - YT, Age 45, Nigeria

The effects last 3 or 4 hours, and it takes 30 to 45 minutes to kick in. - Art, Age 62, Texas

It worked faster than a 1/2 hour and I had the first complete sexual experience in over 6 YEARS! William, Age 42, Texas

It begins to work in about 15 minutes to a half an hour and lasts for 3 hours or so

I find that 25 mg two hours prior to sex is best for me, and allows sensitivity, to remain at its peak. - Phil, Age 60, California

The first time I took it, my wife and I had already made love that afternoon. Viagra worked well in producing another HARD erection for us that night. The next time I tried it was an hour before bedtime. This produced even greater results. - JimmyB, Age 45

I've found I need to take it at least 30 minutes before sex. Not only is my erection harder, but the quantity of my orgasm and the force of it is greatly increased by Viagra

I take it about an hour before making love (which for us is usually mid afternoon.)

The doctor told me when he prescribed it that the first time I tried some it would take a little while to work, like almost an hour, and to be patient. So I took it, and set back to wait. I was surprised to find out that I didn't have to wait near that long. I was ready to go in fifteen minutes, and went a little longer than she wanted me to go.

But 30 mins after taking a 50mg dose of Viagra (with no side effects other than a very mild headache), then - boing!! - my penis is as stiff as it used to be when I was 15! - Richard, Age 53, UK